Gene information
Official symbol KDR
Official full name kinase insert domain receptor
Gene type protein-coding gene
Chromosome4q12
Alias symbolFLK1; VEGFR; VEGFR2; CD309
Gene familyReceptor tyrosine kinases; CD molecules; V-set domain containing; I-set domain containing
Resources
Entrez Gene 3791
HGNC HGNC:6307
Ensembl ENSG00000128052
Vega OTTHUMG00000128734
UCSC uc003has.4
GO terms: 139 records
GO Description Category LogP Number of genes Detail
GO:0000165 MAPK cascade GO Biological Processes -7.43732657 14 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001569 branching involved in blood vessel morphogenesis GO Biological Processes -5.46031079 9 More
GO:0001570 vasculogenesis GO Biological Processes -9.47667325 18 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001763 morphogenesis of a branching structure GO Biological Processes -11.2402819 31 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0001952 regulation of cell-matrix adhesion GO Biological Processes -7.29794194 21 More
GO:0001954 positive regulation of cell-matrix adhesion GO Biological Processes -5.41310394 7 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0002040 sprouting angiogenesis GO Biological Processes -8.76593708 16 More
GO:0002042 cell migration involved in sprouting angiogenesis GO Biological Processes -4.00389964 4 More
GO:0002244 hematopoietic progenitor cell differentiation GO Biological Processes -2.29650667 5 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0003157 endocardium development GO Biological Processes -6.82460421 7 More
GO:0003158 endothelium development GO Biological Processes -13.1102461 25 More
GO:0003254 regulation of membrane depolarization GO Biological Processes -7.35217119 13 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0004713 protein tyrosine kinase activity GO Molecular Functions -1.63313364 5 More
GO:0004714 transmembrane receptor protein tyrosine kinase activity GO Molecular Functions -3.13739094 5 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007548 sex differentiation GO Biological Processes -7.13021119 33 More
GO:0008360 regulation of cell shape GO Biological Processes -5.20319448 20 More
GO:0008585 female gonad development GO Biological Processes -5.58425106 9 More
GO:0009791 post-embryonic development GO Biological Processes -4.81501809 14 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010464 regulation of mesenchymal cell proliferation GO Biological Processes -2.94884372 6 More
GO:0010506 regulation of autophagy GO Biological Processes -5.54010569 34 More
GO:0010508 positive regulation of autophagy GO Biological Processes -4.14985165 17 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010631 epithelial cell migration GO Biological Processes -10.0481870 21 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010810 regulation of cell-substrate adhesion GO Biological Processes -12.3653476 37 More
GO:0010811 positive regulation of cell-substrate adhesion GO Biological Processes -6.61578697 11 More
GO:0010821 regulation of mitochondrion organization GO Biological Processes -7.09757912 23 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0016239 positive regulation of macroautophagy GO Biological Processes -4.30642477 12 More
GO:0016241 regulation of macroautophagy GO Biological Processes -3.91265693 18 More
GO:0018108 peptidyl-tyrosine phosphorylation GO Biological Processes -3.43405510 8 More
GO:0018212 peptidyl-tyrosine modification GO Biological Processes -3.37492500 8 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0019722 calcium-mediated signaling GO Biological Processes -11.6647584 29 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0022604 regulation of cell morphogenesis GO Biological Processes -5.63620747 32 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030323 respiratory tube development GO Biological Processes -8.11012280 27 More
GO:0030324 lung development GO Biological Processes -8.32855168 27 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030510 regulation of BMP signaling pathway GO Biological Processes -5.75086352 17 More
GO:0030513 positive regulation of BMP signaling pathway GO Biological Processes -3.65716220 8 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0031072 heat shock protein binding GO Molecular Functions -1.83303292 11 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035584 calcium-mediated signaling using intracellular calcium source GO Biological Processes -2.72529058 5 More
GO:0035924 cellular response to vascular endothelial growth factor stimulus GO Biological Processes -8.07167727 14 More
GO:0038084 vascular endothelial growth factor signaling pathway GO Biological Processes -6.53278734 9 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043491 protein kinase B signaling GO Biological Processes -12.2973970 11 More
GO:0043534 blood vessel endothelial cell migration GO Biological Processes -6.48443546 10 More
GO:0043536 positive regulation of blood vessel endothelial cell migration GO Biological Processes -25.0316183 33 More
GO:0043542 endothelial cell migration GO Biological Processes -10.6625063 19 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045165 cell fate commitment GO Biological Processes -15.5778047 44 More
GO:0045446 endothelial cell differentiation GO Biological Processes -10.3072059 20 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0046545 development of primary female sexual characteristics GO Biological Processes -5.43927805 9 More
GO:0048286 lung alveolus development GO Biological Processes -3.35916365 8 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048568 embryonic organ development GO Biological Processes -17.1204114 64 More
GO:0048592 eye morphogenesis GO Biological Processes -1.58766487 12 More
GO:0048593 camera-type eye morphogenesis GO Biological Processes -1.85747522 11 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048754 branching morphogenesis of an epithelial tube GO Biological Processes -10.2965313 26 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0048880 sensory system development GO Biological Processes -3.47450215 31 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050926 regulation of positive chemotaxis GO Biological Processes -15.5115450 16 More
GO:0050927 positive regulation of positive chemotaxis GO Biological Processes -14.3403642 15 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051769 regulation of nitric-oxide synthase biosynthetic process GO Biological Processes -8.50460337 7 More
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process GO Biological Processes -7.53000143 6 More
GO:0051881 regulation of mitochondrial membrane potential GO Biological Processes -3.75786499 11 More
GO:0051900 regulation of mitochondrial depolarization GO Biological Processes -3.03478521 5 More
GO:0060055 angiogenesis involved in wound healing GO Biological Processes -4.38810525 4 More
GO:0060541 respiratory system development GO Biological Processes -8.30305934 29 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0061138 morphogenesis of a branching epithelium GO Biological Processes -11.1441029 30 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -13.1150464 44 More
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -10.5573443 25 More
GO:0090130 tissue migration GO Biological Processes -11.7623300 24 More
GO:0090132 epithelium migration GO Biological Processes -9.75855830 21 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0150063 visual system development GO Biological Processes -3.59465978 31 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901888 regulation of cell junction assembly GO Biological Processes -8.71146171 30 More
GO:1901890 positive regulation of cell junction assembly GO Biological Processes -5.75086352 17 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1904036 negative regulation of epithelial cell apoptotic process GO Biological Processes -12.0631217 12 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000351 regulation of endothelial cell apoptotic process GO Biological Processes -18.6276983 25 More
GO:2001026 regulation of endothelial cell chemotaxis GO Biological Processes -8.98205881 11 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04370 VEGF signaling pathway KEGG Pathway -4.15091515 6 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
Drug-Gene interaction
view
Related drugs: 126 records
Drug name Interaction type Source PMID View
4sc-203 inhibitor ChemblInteractions view
abicipar pegol TdgClinicalTrial view
aee-788 inhibitor MyCancerGenomeChemblInteractions view
ag-13958 inhibitor ChemblInteractions view
alacizumab pegol antagonist ChemblInteractions view
alisertib DTC view
altiratinib inhibitor ChemblInteractionsTTD view
anlotinib inhibitor ChemblInteractions view
ast-487 inhibitor DTC view
axitinib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsCancerCommonsMyCancerGenomeClinicalTrialPharmGKBTTD 2012495118541897 view
azd-1152-hqpa DTC view
barasertib DTC view
bms-690514 inhibitor TALCMyCancerGenomeChemblInteractionsTTD view
bms-794833 inhibitor ChemblInteractions view
bms-817378 inhibitor ChemblInteractions view
brivanib inhibitor TALCMyCancerGenomeChemblInteractionsPharmGKBTTD 20124951 view
brivanib alaninate inhibitor ChemblInteractions view
cabozantinib inhibitorantagonist TALCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialTTD 2160641221926191 view
cabozantinib s-malate inhibitor ChemblInteractions view
cediranib inhibitor TALCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsTTD 15899831 view
cenisertib inhibitor DTC view
cep-11981 inhibitor ChemblInteractionsTTD view
cep-5214 inhibitor DTCChemblInteractions 14640546 view
cep-7055 inhibitor ChemblInteractions view
cetuximab JAX-CKB 27149458 view
chembl202721 DTC view
chembl379975 DTC view
chembl406845 DTC view
chembl536151 DTC view
chembl546797 DTC view
chiauranib inhibitor ChemblInteractions view
cm-082 inhibitor ChemblInteractions view
cp-459632 inhibitor ChemblInteractions view
cyc-116 inhibitor DTCChemblInteractions view
dasatinib DTC view
delphinidin TTD view
doramapimod DTC view
dovitinib inhibitor TALCDTCTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractions view
elpamotide TTD view
enmd-2076 inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractions view
enmd-981693 inhibitor ChemblInteractions view
entrectinib DTC view
erlotinib DTC view
eupatorin DTC view
famitinib inhibitor ChemblInteractionsTTD view
foretinib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsTTD view
fruquintinib inhibitor TdgClinicalTrialChemblInteractionsTTD view
gemcitabine JAX-CKB 19930156 view
glesatinib inhibitor TALCMyCancerGenomeTdgClinicalTrial view
go-6976 DTC view
golvatinib inhibitor ChemblInteractionsTTD view
gw441756x DTC view
gw559768x DTC 17884497 view
gw843682x DTC view
henatinib inhibitor ChemblInteractions view
hesperadin inhibitor DTC 19035792 view
ilorasertib inhibitor DTCChemblInteractions view
itraconazole DTC 21936514 view
ji-101 inhibitor ChemblInteractions view
jnj-7706621 DTC view
kenpaullone DTC view
krn-633 inhibitor ChemblInteractions view
l-21649 inhibitor ChemblInteractions view
lenvatinib inhibitor TALCMyCancerGenomeTdgClinicalTrialTTD 17943726 view
lenvatinib mesylate inhibitor ChemblInteractions view
linifanib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialChemblInteractions view
lucitanib inhibitor JAX-CKBChemblInteractionsMyCancerGenomeClinicalTrial 25193991 view
mgcd-265 inhibitor ChemblInteractions view
midostaurin antagonistinhibitor MyCancerGenomeChemblInteractions 16969355 view
mk-2461 inhibitor TTD view
mln-8054 DTC view
motesanib inhibitor TALCMyCancerGenomeTdgClinicalTrialJAX-CKBChemblInteractionsPharmGKB 2142280320124951 view
muparfostat TdgClinicalTrial view
neratinib TTD view
nintedanib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrial 185595243101667019522465 view
nintedanib esylate inhibitor ChemblInteractions view
orantinib inhibitor TALCMyCancerGenomeChemblInteractions view
osi-632 inhibitor DTCChemblInteractionsTTD view
osi-930 inhibitor TdgClinicalTrialChemblInteractionsTTD view
pazopanib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialCIViCMyCancerGenomeClinicalTrialPharmGKB 2606363327160228172888762541116324036042 view
pazopanib hydrochloride inhibitor ChemblInteractions view
pd-0166285 DTC view
pegdinetanib inhibitor TALCTdgClinicalTrialTTD view
pegpleranib sodium TdgClinicalTrial view
pexmetinib TdgClinicalTrial view
pf-00337210 inhibitor ChemblInteractionsTTD 23835340 view
pf-00562271 DTC view
ponatinib inhibitor MyCancerGenome 19878872 view
puquitinib inhibitor ChemblInteractions view
r-406 DTC view
rabeprazole sodium inhibitor MyCancerGenomeTTD view
raf-265 inhibitor MyCancerGenomeTdgClinicalTrialChemblInteractionsTTD view
ramucirumab inhibitorantagonistantibody TALCMyCancerGenomeTdgClinicalTrialJAX-CKBChemblInteractionsTTD 200481822182794 view
regorafenib inhibitor TALCMyCancerGenomeTdgClinicalTrialJAX-CKBChemblInteractionsMyCancerGenomeClinicalTrialTTD 27004155 view
rg-1530 inhibitor DTCChemblInteractions view
rivoceranib inhibitor MyCancerGenomeChemblInteractionsTTD view
rivoceranib mesylate TTD view
romiplostim TTD view
sb-220025 DTC view
semaxanib inhibitor ChemblInteractions 164492401698350616736151 view
sns-314 DTC view
sorafenib antagonistinhibitor TALCDTCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialJAX-CKBTENDCIViCMyCancerGenomeClinicalTrialPharmGKBTTD 1682405016418310263445912518270716503817167573552012495125743214283627161644632325816720197236552451074620630084 view
sorafenib tosylate inhibitor ChemblInteractions view
sotrastaurin DTC view
sp-600125 DTC view
su-014813 inhibitor ChemblInteractions view
sunitinib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialJAX-CKBTENDCIViCMyCancerGenomeClinicalTrialPharmGKBTTD 27149458201425932563961719248971164183102358391116533791218852872196330520124951125384851475371011752352280116231972365512873999 view
sunitinib malate inhibitor ChemblInteractions view
surufatinib inhibitor ChemblInteractionsTTD view
tae-684 DTC view
tak-593 inhibitor ChemblInteractionsTTD view
tak-715 DTC view
tas-115 inhibitor JAX-CKBChemblInteractions 24140932 view
telatinib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsTTD view
telbermin agonist ChemblInteractions view
tesevatinib inhibitor TALCMyCancerGenomeTdgClinicalTrial view
tg100-801 inhibitor ChemblInteractions view
tivozanib inhibitor TALCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsTTD view
tozasertib DTC view
vadimezan TdgClinicalTrial view
vandetanib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialJAX-CKBChemblInteractionsMyCancerGenomeClinicalTrialPharmGKBTTD 2657868420124951 view
vatalanib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialChemblInteractionsTTD 17584317 view
x-82 inhibitor MyCancerGenomeChemblInteractions view
xl-820 inhibitor ChemblInteractions view
xl-999 inhibitor ChemblInteractions view
zd-4190 inhibitor ChemblInteractions view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_002253.4:c.-604T>C genomics myocardial infarction[diagnosis] myocardial infarction Kariz SD Petrovic Clin Biochem. 2014
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